CUT&Tag Enables High-Resolution Chromatin Profiling at a Fraction of the Cell Input and Sequencing Depth of ChIP-seq

Epigenetics refers to alterations in gene expression that occur independently of the underlying DNA sequence (i.e. mutations). Epigenetics research is inextricably linked to the study of chromatin architecture, as chromatin and chromatin-associated proteins are essential to the packaging and accessibility of the genome. The base subunit of chromatin is the nucleosome, which is composed of […]

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Finding the Best H3K27ac Antibody for Profiling Enhancers

Epigenetics describes the phenomenon in which phenotypic differences are observed without alterations to the underlying genome sequence, and is largely regulated by changes in gene expression patterns. Epigenetics and gene expression directly relate to chromatin structure, the three-dimensional compaction of DNA in the nucleus. The fundamental unit of chromatin is the nucleosome, composed of a […]

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A Few Methods for Identifying Histone Modifications

Epigenetic research, particularly work focused on chromatin structure, is shedding new light on the factors involved in gene expression and transcriptional silencing. Though the field is constantly evolving, the implications this research has for understanding disease development, diagnosis, and potential treatments is immense. Indeed, many of the epigenetic factors involved in chromatin accessibility and gene […]

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EpiCypher’s SNAP-ChIP Certified Antibodies Enable Superior ChIP-seq

Epigenetics research is focused on understanding how chromatin structure impacts gene expression, the requirement for this architecture in normal cellular processes, and how aberrant regulation of chromatin relates to human disease. In fact, multiple epigenetic mechanisms have been linked to human cancer, and each have distinct roles in regulating chromatin. 1. DNA methylation: DNA methylation […]

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Customized Nucleosome Assembly

Chromatin structure refers to the exquisite three-dimensional architecture of DNA in a cell, which impacts gene expression by altering genome accessibility to transcription factors and other regulatory proteins. This structure is fundamental to many cellular processes, including differentiation, proliferation and survival, and aberrant regulation of chromatin is linked to multiple human diseases, such as cancer. […]

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EpiCypher’s SNAP-ChIP Certified H3K4me3 Antibody Is Best-In-Class

Epigenetics research is transforming how researchers study complex biological processes, particularly those related to gene expression. Chromatin structure directly impacts the accessibility of transcription factors to target loci, and thus has important roles in cellular development, proliferation, and survival. In addition, there is extensive research on epigenetic factors that are correlated with and/or contribute to […]

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Why You Need To Choose the Right ChIP Antibody

The field of epigenetics and the study of chromatin structure have begun to shed new light on the regulation of gene expression, and how these processes are altered in disease. Chromatin structure is controlled in part by histone post-translational modifications (PTMs), which impact the accessibility of chromatin to transcription factors and other regulatory proteins. Interestingly, […]

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The Importance Of Chromatin Remodeling In Understanding Gene Expression

DNA, at its core, is a genetic blueprint that contains all the relevant information needed to support life. Embedded within the DNA sequence are discrete regions known as genes; these sequences are expressed as proteins, which are responsible for all the actions and mechanisms in cells. The genetic code contained within each cell is large, […]

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EpiCypher’s CUTANA CUT&RUN Offers Significant Benefits Over Alternative Chromatin Profiling Assays

Epigenetics refers to alterations in gene expression, independent of the underlying DNA sequence. In the field of epigenetics, accurate chromatin profiling is essential to understanding the factors that affect gene expression. Chromatin refers to the dynamic structures used to compact DNA into the nucleus. At the most basic level, chromatin is composed of nucleosomes, which […]

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